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Nonetheless, Ca 2+ release in response to the sarcoplasmic/endoplasmic reticulum (ER) calcium ATPase (SERCA) pump blocker cyclopiazonic acid demonstrated the sheer availability of ER calcium, ruling out the role of ER calcium in triagonist-induced Ca 2+ signalling in beta cells

See Exhibit 1 below

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Still, it is FDA-approved specifically for obesity, resulting in more focused prior authorization criteria that emphasize BMI and comorbidity requirements