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More recent semaglutide data suggest improvements in sperm morphology and testosterone while preserving normal gonadotropin signaling. Philip Werthman, MD One of the most important clinical distinctions is that GLP-1 therapies appear fundamentally different from testosterone replacement therapy for men who wish to preserve fertility, he noted

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J., Wang, W., Hatzichristodoulou, G., & Hellstrom, W

Discontinuation of treatment (37%) was the most common reason for censoring (Supplementary Table 20)