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A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss

Reports submitted to the FDA's MedWatch system and documented in peptide safety reviews describe nausea, transient hypotension, lightheadedness, flushing, and mild headache following doses above the typical range 10

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