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Supplementary material The Supplementary Material for this article can be found online at: Glossary ALB albumin, Anpep: alanyl-aminopeptidase AOD average optical density (IOD area) CREA creatinine CKD chronic kidney disease CUR curtain gas Cys-Gly l-cysteine-l-glycine DAB 3,3-diaminobenzidine ER estrogen receptor alpha ER estrogen receptor beta ESI electron spray ionization GABA gamma-aminobutyric acid GAPDH glyceraldehyde 3-phosphate dehydrogenase Ggt1 gamma-glutamyltransferase 1 GLU glucose GO Gene Ontology GSH-Px glutathione peroxidase GSH/GSSG ratio reduced/oxidized glutathione ratio H&E hematoxylin and eosin HPL Hypericum perforatum L

2) Lowers Inflammation Glutathione (GSH) blocks the production of most inflammatory cytokines

Mitochondrial quality control proteases and their modulation for cancer therapy

IGF-1 DES + Growth Hormone: GH elevates systemic IGF-1 levels while IGF-1 DES provides the immediate, localized punch (an advanced protocol with serious expenses and a great deal of complexity) IGF-1 DES + Insulin: EXTREME caution required here as both compou8nds lower blood sugar, and the synergy on protein synthesis is real (but so is the risk of dangerous hypoglycemia)

In rare cases: headache, dizziness, anxiety, or gastrointestinal disturbances