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Real-world data from electronic health records tells a similar story, though the gap narrows somewhat in patients who also have type 2 diabetes

Mild Pelvic or Lower Abdominal Pain Some people notice a dull ache or pressure in the lower belly or pelvic area

Some patients find that taking their injection in the evening and sleeping through the peak nausea window works well

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Participants who continued treatment maintained significantly more weight loss than those who transitioned to placebo, reinforcing that tirzepatides benefits are dependent on ongoing use and that no new or unexpected safety signals emerged with extended treatment duration