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15 If the biological agent is intended for systemic distribution, then strategies to increase absorption should be considered

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Species differences in metabolism, receptor expression, and pharmacokinetics mean that effective doses in rats do not predict safe or effective doses in humans

It was recently demonstrated that decreased NAD + content in white adipose tissue is associated with severe insulin resistance and IGT due to hypoadiponectinemia at least partly via increased phosphorylation of serine 273 and acetylation of peroxisome proliferator-activated receptor (PPAR) in pan adipocyte-specific NKO (ANKO) mice [35,78,79]

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