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Surprisingly, advances in comprehensive transcriptomic profiling have drastically opened the door to a new field, evoking previous comparisons to the fascinating era of cellular neurophysiology and neuroplasticity research

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Both histological and imaging analyses implicate metabolic stress as a contributor to lesion evolution in MS 57,58,59,60,61,62,63,64 , with reduced focal cerebral blood flow associated with chronic hypoxia, lesion formation and axonal degeneration, and evidence of axonal metabolic dysfunction