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17 Injured hepatocytes release soluble factors that activate HSCs to differentiate into myofibroblastic HSCs, as evidenced by cellular enlargement and proliferation, an increase in rough endoplasmic reticulum, loss of vitamin A droplets, expression of actin filaments, and increased expression of fibril-forming collagen types I, III, and V

The increased level of those PUFAs could be due on one hand, to an increased biosynthesis linked to a high expression of the fatty acid desaturases 1 and 2 (FADS1/2) as shown in TNBC [36]

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Clinical Evidence Supporting Tirzepatide for Weight Loss Clinical trials have demonstrated that tirzepatide produces meaningful weight reduction across diverse patient populations