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Selenium-containing chrysin and quercetin derivatives: Attractive scaffolds for cancer therapy

195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

Elgazzar UB, Ismael I, Ghanema A, Kalaba ZM

However, the effect appears to differ according to baseline LVEF, with worse results in patients with reduced ejection fraction

Credits : Interview conducted and produced by Evie Vouillemin