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For instance, the reader of m 6 A, insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), undergoes lactylation at K76, promoting the m 6 A modification of phosphoenolpyruvate carboxykinase 2 (PCK2) and nuclear factor erythroid 2-related factor 2 ( NRF2 ) mRNAs, which reprogram serine metabolism in HCC cells

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By inhibiting TRI expression and phosphorylation, it blocks signal transmission, thus preventing HSC activation

Both contractility (FS and maximal velocity of contraction, dL / dt ) and relaxation (maximal velocity of relaxation, + dL / dt ) were diminished in the iron group (Figure 5A)

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