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Sinha, Deepankar K et al

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Careful attention to fluid intake is important, especially during the first weeks of treatment and during dose escalation

A pilot study of phentermine added to liraglutide (a related GLP-1 agonist) showed no meaningful additional weight loss

Results and discussion Primary fragment screening by X-ray crystallography Due to its broad affinity detection range (nanomolar to millimolar) and unique ability to initiate rational drug design 30 , we carried out a crystallographic fragment screen against TRF1 TRFH at the XChem facility of the Diamond Light Source 30