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Evidence supports the efficacy of restrictive diets such as a low histamine diet [9], a low sulfur diet [10], a diet with low H2S producing bacteria [11] and a plant-based diet in significantly altering the composition of the gut microbiome, increasing beneficial commensals in the gut, such as Bifidobacterium bifidum and Lactobacillus acidophilus , while reducing pathogenic Bacteroides fragilis and Clostridium perfringens [5]

The hydrolysis of drugs containing the amide group is very slow while the hydrolysis of the ester group is faster [8]