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Label strategy has become both a clinical and business lever

A typical starting dose might be 1.5 mg or 2.5 mg, administered once per week

Both are listed as weekly subcutaneous injections, and both show nausea, vomiting, and GI upset as common side effects

Despite favorable cost-effectiveness, ICER projected affordability concerns: at current net prices of $6,830 for semaglutide and $7,973 for tirzepatide, fewer than 1% of eligible adults in the United States could be treated before surpassing ICERs budget impact threshold of $880 million annually

There is significant geographical variation in the prevalence of AR, asthma, and other similar diseases (Varshney and Varshney, 2015)