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Chronic administration of melatonin: Physiological and clinical considerations

In conditions like Alzheimers disease and Parkinsons disease, ongoing damage signals keep microglia stuck in a state of chronic overactivation, pushing them toward a pro-inflammatory phenotype and making them release a lot of inflammatory factors

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We also studied the effects of the two peptides on intracellular calcium mobilization and the membrane potentials of isolated vagal afferent neurons