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These findings suggest that antidepressants should be considered not merely as symptomatic mental health treatments, but as systemic immunomodulators that can stabilize the gut source of neuroinflammation, potentially reducing the frequency of IBD clinical flares ( 6 Limitations of the literature and future perspectives Despite significant advances in understanding the gut-brain link in IBD and depression, the field faces several critical limitations that must be addressed to translate mechanistic knowledge into effective clinical interventions

doi:10.1093/femsyr/fox028 DeKoven JG, Warshaw EM, Reeder MJ, Atwater AR, Silverberg JI, Belsito DV, Sasseville D, Zug KA, Taylor JS, Pratt MD, Maibach HI, Fowler JF Jr, Adler BL, Houle MC, Mowad CM, Botto N, Yu J, Dunnick CA

Research shows that oxidative stress directly affects sleep quality