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References Hruby VJ, et al

Moreover, the activities of Cu-Zn and Mn-dependent SOD, GPx, and catalase (CAT) were significantly downregulated in the abdominal adipose tissue of ovariectomized metabolic syndrome female rat model (to mimic the postmenopausal status) when compared to metabolic syndrome group without receiving treatment or the group received external estrogens [23]

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That said, these effects are not yet well established clinically, and more research is needed to determine whether they are directly caused by the medication or influenced by factors such as weight loss, metabolic changes, or individual physiology