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All subjects were enrolled in a standard wound care protocol, where only the subjects with sharp ulcer wound or debridement were entered into this randomized, placebo controlled clinical trial

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10 , e2204998 (2023)

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By inhibiting PP6-mediated dephosphorylation, this degradation activates focal adhesion kinase (FAK) and MOB1, reducing focal adhesion density and size while enhancing migratory capacity ( In summary, small GTPasesparticularly the Rab40 familyfunction as substrate receptors that assemble with CUL5 to form ubiquitin ligase complexes, thereby regulating cell migration through ubiquitination and degradation of diverse substrate proteins