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Cellular antioxidant systems rely on dynamic cycling of NAD/NADH and NADP/NADPH, glutathione turnover, and cofactor-dependent enzymatic reactions [83, 84]

References 1 GoreACChappellVAFentonSEFlawsJANadalAPrinsGSet al

Glycerol kinase deficiency (GKD), an X-linked disorder causing elevated blood and urinary glycerol levels, can be associated with adrenal abnormalities, particularly in its complex form, involving contiguous gene deletions affecting the GKD locus along with CAH and/or Duchenne muscular dystrophy ( DMD ) genes (96)

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For some payers, enhanced prior authorizations and wrap-around requirements may outweigh rebate savings because a higher percentage of patients will see better outcomes