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Additionally, GIPR antagonists also exhibit improvement of metabolism on obese mice57 and GIPR agonists or antagonists both show therapeutical effects in combination with GLP-1R agonists.58 A GLP-1R agonist/GIPR antibody (antagonist) fused protein was reported promoting body weight loss.59 Nevertheless, whether a GLP-1R agonist/GIPR antagonist can improve T2DM needs more evidences