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Melanotan II acts on multiple melanocortin receptors: MC1R: May activate melanin production in melanocytesresponsible for skin pigmentation

We hypothesize that conformer 1 is required for G protein activation, and that adoption of this receptor conformation is favored under conditions used to form a stable complex that can be imaged (inclusion of dominant negative G protein and nanobody 35, apyrase treatment)

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