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These may include allergic reactions, skin rashes, and gastrointestinal disturbances

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Notably, the intranasal delivery of drugs, including small molecules, nanoformulations and gene delivery agents, has shown promising outcomes in various rodent models of several neurological pathologies

Examples include the discovery of three distinct urolithin metabotypes of ellagitannins in the general population, that have been related to the presence of specific bacteria such as Gordonibacter urolithinfaciens and Ellagibacter isourolithinfaciens (Reference Selma, Beltrn and Garca-Villalba112Reference Toms-Barbern, Garca-Villalba and Gonzlez-Sarras114)

Wang J, Wood RA, Raymond S, Suarez-Farinas M, Yang N, Sicherer SH, et al