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Substantial fat mass loss after intensive weight loss will likely tend to reduce aromatase activity and regulate estradiol/testosterone equilibrium, resulting in decreased estradiol production, and will favor LH increase which contributes to stimulating testosterone production and substrate availability for estradiol production

Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation

Schyns, G., van den Akker, K., Roefs, A., Houben, K

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