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They are a major defence system in deactivating toxic materials (as parent compounds or metabolites) via glutathione conjugation within the body [1]

doi:10.1177/2398212819858249

In addition, ghrelin was reported to exert a prokinetic effect on the small bowel, where it stimulates activity front of the migrating motor complex (MMC) through cholinergic mechanisms (44)

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[6] [7] [10] GPx1 typically uses glutathione (GSH) as the reductant, but when glutathione synthetase (GSS) is, as in brain mitochondria, -glutamylcysteine can serve as the reductant instead