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These antioxidants decreased ROS production and abolished neuroinflammation in OXA-treated mice without affecting antitumor activity nor hematological toxicity of OXA in vivo ( Some manganese (Mn)-based MRI contrast agents, such as mangafodipir and calmangafodipir, possess a mimic mitochondrial enzyme manganese superoxide dismutase (MnSOD) activity and, thus, could be utilized as a cytoprotector in PIPN

The exposure of plants to environmental stress conditions like high light leads to very quick oxidation of AsA to MDHA in chloroplast (Polle, 2001)

While some formulations are designed to enhance oral absorption, they don't always fully overcome these inherent biological hurdles