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RT-qPCR analyses validated the upregulation of ATF4 target genes, including SLC1A1, SLC7A8 , phosphoserine aminotransferase 1 ( PSAT1 ), and serine hydroxymethyltransferase 2 ( SHMT2 ) in T315I-Bcr-Abl cells (Fig

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Furthermore, pretreatment with free lactoferrin reduced this uptake, confirming lactoferrin receptor-mediated endocytosis

Valued at approximately $85 million in 2023, it is projected to grow at a CAGR of over 7.5% through 2030