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This on its own may cause a reduction in pharmacological outcomes of therapy, which may be mistaken for tachyphylaxis

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Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis

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Acetate could directly activate the nucleotide-binding oligomerization domain containing 3 (NLRP3) inflammasome in mouse IECs, leading to the release of IL-18, and then promote the integrity of the intestinal barrier by activating the IL-18 receptor on mouse epithelial cells [141]