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88 The engagement of lipids in ERAD is exemplified by the ER-resident intramembrane rhomboid protease RHBDL4, which is associated with the ER lipid raft-associated protein 1 (ERLIN1)-ERLIN2 complex and catalyzes the cleavage of aggregation-prone proteins, targeting proteolytic fragments for ERAD

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doi: 10.1093/molbev/msm244 36 HaussmannM

Combining topical application at the wound site with systemic injection represents a comprehensive approach for significant wounds

Coverage context No Canadian provincial health plan covers Wegovy when prescribed for weight management as of January 2026 [Source: ogaei.ca/blog/wegovy-cost-in-canada/]