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KPV appears to enter cells and downregulate pro-inflammatory signaling, including the NF-kB pathway that drives inflammatory gene expression (Dalmasso et al., Am J Physiol Gastrointest Liver Physiol, 2008)

Evidence below covers each compound separately and is extrapolated to the blend

[PubMed] [BenthamScience] 91

Subsequent increases in intracellular cAMP levels activates PKA and EPAC ( 2+ concentrations, allowing for the potentiation of glucose-stimulated insulin granule exocytosis ( Figure 1 )