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It targets tumor cells and inhibits tumor progression by reducing the production of 2-hydroxyglutarate (2-HG) mediated by isocitrate dehydrogenase 1 (IDH1mt) (84)

Arch Iran Med 18(1):1823 Almuhayawi MS (2020) Propolis as a novel antibacterial agent

2 Further investigation revealed that this type of cell death does not share classic features of apoptosis such as caspase activation and chromatin fragmentation and is characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels

Consequently , calcium-dependent vesicle fusion occurs via SNARE proteins, resulting in GH exocytosis from somatotrophs

It also helps in inhibiting production of melanin, reduces and protects skin from UV damage