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However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

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This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC2106 (P.B.R.)), the UK Medical Research Council (CC2106 (P.B.R.)), and the Wellcome Trust (CC2106 (P.B.R.))

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