QW: Methodology, Investigation, Formal Analysis, Funding acquisition, Project administration, Writing review & editing
It was earlier shown, that PINK, PRKIN, MFN-1, MIEF and UCP-1 mediates mitophagy maintaining intracellular homeostasis and becoming a key point in mitochondrial quality control which was found to correlate with insulin resistance [59]
These findings suggest higher rigidity within the complex (Fig
Without IGFBP interference, LR3 remains active in circulation for 20-30 hours : nearly 100 times longer than natural IGF-1
Therefore, there is a pressing need for further research, especially well-designed clinical trials, to elucidate the mechanistic role of exercise-induced FGF21 in human atherosclerosis and to explore the long-term therapeutic potential of FGF21 induced by exercise in the prevention and treatment of atherosclerosis