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Vitamin B12 plays a key role in various bodily functions, making it essential for maintaining optimal health

Less common: Nausea, dizziness, or headache

Segata, N

**Never shake.** Shaking denatures peptide bonds and can reduce potency

However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence