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This integrated approach has allowed us to determine the structural basis of GABA reuptake inhibition through the transporter GAT1, uncover the molecular mechanisms of inverse agonism at the kappa-opioid receptor, resolve the activation architecture of complement receptors C3aR and C5aR1, and capture nucleotide-release intermediates at the mu-opioid receptor work published in Nature, Nature Chemical Biology, Nature Communications, and Cell