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Based on these initial studies and comprehensive characterization, liraglutide was selected as having the best properties, combining high receptor potency with pharmacokinetics (PK) that are optimum for OD dosing ( Following the selection of liraglutide as the first GLP-1-based analog suitable for OD dosing, further analysis of its structural activity was published ( The Discovery of Semaglutide Successful clinical trials with exenatide and liraglutide led to an increased interest in GLP-1-based therapies
"Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat"
doi: 10.3389/fmicb.2022.1000419
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