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However, with the advancement of the knowledge related to oxidative stress, as well as the growing scientific literature linked to the complex ADME and bioavailability of phenolic compounds in vivo , the idea of (poly)phenol effects on health to be associated merely with their antioxidant potential has been abandoned over the years (Reference Ruskovska, Maksimova and Milenkovic71)

As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

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All documentation and evaluation of this compound remain limited to investigational, non-clinical laboratory contexts

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