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Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice

The method of any one of embodiments 49-56, wherein the composition comprises between about 0.01% to about 10% by weight of the silicon dioxide, about 0.01% to about 7% by weight of the silicon dioxide, about 0.01% to about 5% by weight of the silicon dioxide, about 0.01% to about 3% by weight of the silicon dioxide, about 0.01% to about 2% by weight of the silicon dioxide, or about 0.01% to about 1% by weight of the silicon dioxide

is supported in part by a Banting and Best Diabetes Centre Novo Nordisk Chair in Incretin Biology, and a Sinai Health Novo Nordisk Foundation Fund in Regulatory Peptides

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