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The pharmacokinetic profiles are fundamentally different

The Mayo Clinic recommends seeing a doctor or heading to the emergency room if your headache occurs in the following ways: After a head injury Comes on very quickly like a thunderclap Accompanied by a fever, a stiff neck, seizures, or numbness & weakness in any part of the body these are symptoms of a stroke If its a new headache pain after age 50 Chronic headache pain after coughing, physical activity, straining, or sudden movements Migraines are more common in women than men and seem to have a genetic component

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Lyons S, Lorigan P, Green AC, Ferguson A, Epton T

My experience is one data point