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doi: 10.1016/j.mito.2020.05.004 67

93 Histone modification and chromatin remodelling Recent studies have revealed a characteristic histone acetylation signature in the brains of ASD patients, providing strong evidence that histone modifications, especially acetylation, lead to ASD-like behaviours

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For example, accelerated tolerance with morphine + NOS inhibitor treatment and blunted tolerance with morphine + L-arginine treatment has been reported (Tayfun Uzbay and Oglesby, 2001)