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Potentially giving increased resistance to infections and enhanced immune surveillance

[3] This discovery opened the door to an entire class of diabetes treatments

Contraindications include known hypersensitivity to mannitol (present in the formulation), active malignancy, pregnancy, disruption of the hypothalamic-pituitary axis (after surgery, radiation or major trauma), and severe hypersensitivity to any component of the lyophilized product

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Marked reduction in bile acid synthesis in cholesterol 7-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia