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Understanding why requires appreciating how weight loss itself affects thyroid function: Weight loss reduces leptin levels , which can decrease TRH (thyrotropin-releasing hormone) secretion from the hypothalamus, potentially lowering TSH Improved insulin sensitivity may alter thyroid hormone metabolism and conversion of T4 to T3 Reduced inflammation from fat loss can change the thyroid hormonal milieu Changes in body composition affect thyroid hormone distribution and binding A retrospective study of over 21,000 patients found that hypothyroid individuals using semaglutide experienced modest TSH decreases alongside weight loss

These beneficial effects are consistent with anecdotal reports that patients prescribed semaglutide describe reduced desire to drink alcohol while on the medication 9 and with recent clinical reports

In one landmark study, participants who took semaglutide at a higher dose (2.4 mg per week) lost on average over 15% of their body weight, compared to a placebo group

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