oral glutathione skin whitening evidence as a skin‐lightening agent and in melasma: a systematic review - Sarkar - 2025 - International Journal of Dermatology Glutathione is a powerful antioxidant

Therapeutic effects of turmeric topical cream in vitiligo: a randomized, doubleblind, placebocontrolled pilot study

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Yes, its antioxidant properties help reduce oxidative stress, which may support healthier, more youthful-looking skin

5.0 Pharmacological properties 5.1 Mechanism of action Glutathione is an extremely important cell protectant which directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules

Independent studies show SIRT6 can drive pro-inflammatory cytokine release and that nicotine blunts microglial activation in Parkinsons models, aligning with this mechanism