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[DOI] [PubMed] [Google Scholar] 71.SADEK S A, MARZOUK M, MOHAMED H R H, et al

Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice

The hydroxyl group of the Tyr residue at this site forms a hydrogen bond with the thiol group of GSH, ionizing GSH to form a stable, highly active thiolate anion, which drives GST binding, peroxidase, and isomerase reactions