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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

There are always limitations to observational data, so long-term follow-up from prospective randomized trials would help determine whether these effects are genuine. Future research should explore the potential cancer-protective effects of GLP-1 receptor agonists among people without diabetes, Mavromatis said, considering they represent an increasingly larger proportion of people who use these medications

4 Investigations into normal melanocyte homeostasis led to the discovery that keratinocytes control melanocytic growth