what is the difference between semaglutide and glp-1 Vs Zepbound For Weight Loss Which GLP-1 Is Best for

IV fluids if vomiting prevents oral intake Red-flag threshold / inability to keep any liquids down for more than 24 hours requires same-day clinical evaluation Key electrolytes at risk / sodium, potassium, and chloride can fall with severe or prolonged vomiting and diarrhea Dose relationship / GI side effects peak during dose escalation and often improve after 4-8 weeks at a stable dose Concurrent risk / patients on diuretics, SGLT-2 inhibitors, or ACE inhibitors face compounded dehydration risk Why GLP-1 Drugs Cause Dehydration in the First Place GLP-1 receptor agonists work partly by slowing gastric emptying and acting on brainstem nausea centers

Lancet 389 , 197210 (2017)

10.1016/0896-6273(93)90120-G [DOI] [PubMed] [Google Scholar] Tsao P

Neurotoxicity of tryptophan metabolites

Once it spots them, glutathione neutralises them before they cause harm