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A lack of conjugation between the A and B rings usually results in decreased antioxidant activity, and the absorption spectra are reflected by an intense band II and only a weak shoulder for band I (Jomova et al

Excessive iron promotes hydroxyl radical (OH) generation via the Fenton reaction, thereby exacerbating lipid peroxidation and oxidative injury, which in turn facilitates A aggregation, tau hyperphosphorylation, and neuronal degeneration (Pei et al., 2025