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MMP2 and MMP9 activity and TIMP1 protein levels were enhanced in haemodynamic models of HFpEF, while metabolic models showed no changes in MMP2, -8, -9, -11, -14, -15, TIMP-1, -2 and -3 mRNA expression.63 In a PARAGON-HF collagen biomarker substudy, sacubitril/valsartan decreased TIMP1 by 8% compared with valsartan alone, consistently in men and women and patients with LV ejection fraction (LVEF) above or below the median of 57%

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In 2019, PT141 (bremelanotide) was approved by the United States Food and Drug Administration (FDA) for the treatment of Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women

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