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The real issue often lies deeper, at the cellular level
2021 Jul 15;12(7):91631
These individuals often need larger doses of B12 to fulfill the important roles B12 has in human physiology
Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice
[1] [2] Some patients report reduced symptoms within weeks of starting treatment, whilst others may require several months of consistent supplementation before noticing significant improvement
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