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In addition to well-known mental factors, MDD is also related to genetic factors, social stress, and even other common chronic diseases
References ACS Chemical Biology (2023) Synthetic ERR// Agonist Induces an ERR-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Journal of Pharmacology and Experimental Therapeutics (2024) A Synthetic ERR Agonist Alleviates Metabolic Syndrome Circulation (2024) Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function American Journal of Pathology (2023) Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney
Novo was first to hit the jack pot with semaglutide, approved to treat diabetes in the UK in 2019 (as Ozempic)
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Complications of type 2 diabetes
By enhancing mitochondrial function and fatty acid metabolism, it improves insulin signaling in muscle cells
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