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1 ( Arx and Dnmt1 expression led to an increase in alpha-cell-derived bihormonal insulin + /glucagon + cells in mouse islets ( Role of alpha-cell GLP-1 production in metabolic dysfunction Alpha-cell GLP-1 production as an adaptive response to metabolic dysfunction Although the in vivo physiological function of intra-islet GLP-1 has been questioned since levels of GLP-1 in the pancreas of healthy mice are considerably low and sometimes undetected ( Figure 4 )

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