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It takes 4 to 5 weeks for semaglutide to completely clear from your system after your last injection

The appetite-suppressing effects become more pronounced as you build to steady-state concentration over 4 to 5 weeks and titrate up to higher doses

No dose adjustment is recommended for patients with renal or hepatic impairment, though renal function should be monitored in patients experiencing significant gastrointestinal adverse effects that could lead to dehydration

These concerns are completely valid and totally understandable

One additional result of this study was a reduction in smoking for those who used cigarettes